Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit
| Autor: | Julia Sampaio Coelho, Janita Ferreira, Ana Carolina Bueno e Silva, Wanessa Trindade Clemente, Viviane Rosado, Lêni Márcia Anchieta, Roberta Maia de Castro Romanelli, Paulo Henrique Orlandi Mourão |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Referral Infection control Microbial Sensitivity Tests Drug resistance Pediatrics RJ1-570 Cohort Studies 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Microbial 030225 pediatrics Internal medicine Gram-Negative Bacteria medicine Humans 030212 general & internal medicine Neonatology Cross Infection business.industry Infant Newborn Infant Bacterial Infections Antimicrobial Institutional review board Newborn Anti-Bacterial Agents Pediatrics Perinatology and Child Health Anti-infective agents Gram-Negative Bacterial Infections business Delivery of Health Care Cohort study |
| Zdroj: | Jornal de Pediatria v.97 n.3 2021 Jornal de Pediatria Sociedade Brasileira de Pediatria (SBP) instacron:SBPE Jornal de Pediatria, Volume: 97, Issue: 3, Pages: 329-334, Published: 02 JUL 2021 Jornal de Pediatria, Vol 97, Iss 3, Pp 329-334 (2021) |
| Popis: | Objective The use of broad-spectrum antimicrobials, such as third and fourth-generation, are responsible for emergence of multidrug-resistant microorganisms in neonatal units. Furthermore, antimicrobial daily doses are not standardized in neonatology. This study aimed to investigate the association between the use of antimicrobial broad spectrum to bacterial sensitivity profile in a referral unit of neonatal progressive care. Methods This is a cohort study conducted in a referral neonatal progressive care unit from January 2008 to December 2016. The data of all hospitalized neonates was collected daily. The infection criteria used were the standardized national criteria, based on definitions of Center for Diseases Control and Prevention. In this study, the use of antimicrobials was evaluated as antimicrobial-day (ATM-day) and the ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was also calculated. The study was approved by the Institutional Review Board of the Universidade Federal de Minas Gerais (ETIC 312/08 e CAAE 58973616.2.0000.5149). Results From 2008 to 2016, 2751 neonates were hospitalized, corresponding to 60,656 patient-days. The ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was 1,3 in the first period and 4,3 in the second period (p = 0,005). Conclusion It was observed that use of broad-spectrum antimicrobials, especially those with coverage for Gram-negative bacteria, was associated with an increase of multidrug-resistant bacteria. |
| Databáze: | OpenAIRE |
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