Intramesenteric Steroid Treatment for Steroid- Refractory Gastrointestinal Graft Versus Host Disease
| Autor: | Mutlu Arat, Aynur Uğur Bilgin, Tanzer Sancak, Pervin Topcuoglu, Nahide Konuk |
|---|---|
| Přispěvatelé: | Necmettin Erbakan Üniversitesi, Dahili Tıp Bilimleri Bölümü İç Hastalıklar Anabilim Dalı |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Steroid injection Pathology lcsh:Internal medicine Allogeneic transplantation Steroid dirençli GvHH Case Report Intramesenteric steroid Gastroenterology Internal medicine medicine lcsh:RC31-1245 business.industry lcsh:RC633-647.5 Hematology lcsh:Diseases of the blood and blood-forming organs medicine.disease Alternative treatment Steroid refractory GvHD and intramesenteric steroid Diarrhea Steroid therapy Graft-versus-host disease surgical procedures operative Methylprednisolone İntramezenterik steroid medicine.symptom Steroid refractory business Steroid-refractory GVHD medicine.drug |
| Zdroj: | Turkish Journal of Haematology Turkish Journal of Hematology, Vol 29, Iss 4, Pp 409-412 (2012) |
| ISSN: | 1308-5263 1300-7777 |
| Popis: | Günümüzde, steroid dirençli gastrointestinal (Gİ) graft versus host hastalığı (GvHH) allogeneik transplantasyon yapılan hastalarda izlenen en sık komplikasyonlardan biridir ve henüz standart bir tedavi yaklaşımı yoktur. Burada, steroid refrakter GvHH olan iki vakanın intramezenterik steroid uygulamasına dair sonuçları bildirilmiştir. Her iki hastada intramezenterik metilprednizolon (MP) enjeksiyonunu takiben diarenin sıklığı ve miktarı tamamen düzelmiştir. Sonuç olarak, intra-arteriel steroid verilimi bu tip olgularda alternative bir tedavi yaklaşımı olabilir. Currently, steroid-refractory severe gastrointestinal (GI) graft versus host disease (GVHD) is among the most important complications of allogeneic transplantation, and as yet there is no standard approach to its treatment. Herein we report two cases with steroid-refractory GI GVHD that received intramesenteric steroid treatment. In both cases the frequency and volume of diarrhea resolved completely following intramesenteric methylprednisolone (MP) injection. In conclusion, intra-arterial steroid injection might be an alternative treatment approach for steroid-refractory GI GVHD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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