Abietane diterpenoids from the roots of some Mexican Salvia species (Labiatae): chemical diversity, phytogeographical significance, and cytotoxic activity
| Autor: | Fredd Vergara, W. Matus, Baldomero Esquivel, María Teresa Ramírez-Apan, Ana Adela Sánchez, Simón Hernández-Ortega |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Models
Molecular Stereochemistry Bioengineering Salvia Biochemistry Plant Roots chemistry.chemical_compound Genus Cell Line Tumor Botany Cytotoxic T cell Humans Molecular Biology Abietane biology Molecular Structure Jungia General Chemistry General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Biological Evolution chemistry Chemical diversity Abietanes Molecular Medicine Subgenus Human cancer |
| Zdroj: | Chemistrybiodiversity. 2(6) |
| ISSN: | 1612-1880 |
| Popis: | From the roots of some Mexican Salvia species, classified in subgenus Jungia, several diterpenoids belonging to abietane (i.e., 3-7), salvifolane (9 → 20,10 → 6)-diabeoabietane) (i.e., 2), and totarane (i.e., 10) carbocyclic skeletons were isolated together with two 20-nor- and one 6,7-secoabietane derivatives, 1 and 9, and 8, respectively. While compounds 2 - 10 were previously known from different sources, compound 1 is a new 20-norabietane derivative, whose structure was deduced by spectroscopic means and confirmed by X-ray-diffraction analysis. The phytogeographical significance of the distribution of 20-norabietanic diterpenoids in the genus suggested an evolutionary link between the Chinese and New-World Salvias. Compounds 2 and 8 were tested for cell-growth inhibition activity against several human cancer cell lines and human normal lymphocytes, while 2 showed a moderate cytotoxic activity, 8 exhibited a moderate yet selective activity against leukemia cell line. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text