Epidemiologic Characterization of Human Papillomavirus Infection in Rural Chaozhou, Eastern Guangdong Province of China

Autor: Wei-Pian Chen, Qi-Li Lin, Min Lin, Zhao-Yun Luo, Bing-Zhong Lin, Long-Xu Xie, Xiang-Zhi Liu, Li-Ye Yang, Shi-Ming Zhang, Lie-Jun Li, Hui Li, Chun Yang, Zhi-Rong Qing, Chan-Yu Chen, Wen-Zhou Chen, Yong-Zhong Zhan, Qiang Chen, Pei-Yao Zheng, Jia-Kun Zheng, Ling-Zhi Mao
Rok vydání: 2012
Předmět:
Rural Population
Viral Diseases
Epidemiology
Cross-sectional study
Uterine Cervical Neoplasms
lcsh:Medicine
Polymerase Chain Reaction
law.invention
law
Prevalence
Papillomaviridae
lcsh:Science
Polymerase chain reaction
Cervical cancer
Multidisciplinary
biology
Incidence (epidemiology)
HPV infection
Obstetrics and Gynecology
virus diseases
Middle Aged
Treatment Outcome
Infectious Diseases
Oncology
Medicine
Female
Research Article
Adult
China
medicine.medical_specialty
Clinical Research Design
Urology
Sexually Transmitted Diseases
HPV vaccines
Real-Time Polymerase Chain Reaction
Diagnostic Medicine
Internal medicine
medicine
Humans
Genitourinary Infections
business.industry
Papillomavirus Infections
lcsh:R
Genetic Variation
Cancers and Neoplasms
Sequence Analysis
DNA
medicine.disease
biology.organism_classification
Virology
Cross-Sectional Studies
DNA
Viral
lcsh:Q
business
Gynecological Tumors
Zdroj: PLoS ONE, Vol 7, Iss 2, p e32149 (2012)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0032149
Popis: Background Human papilloma virus (HPV) infection was the main cause of cervical cancer. There were only a few reports and detailed data about epidemiological research of HPV infection in rural population of China. Materials and Methods The cervical cells of rural Chaozhou women were collected, and multiplex real time PCR was firstly performed to detect high-risk HPV (HR-HPV) infection, which could detect 13 types of HR-HPV (types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68). Then, HPV-positive samples were typed by HPV GenoArray test. Results HR-HPV DNA was detected by multiplex real time-PCR in 3830 of 48559 cases (7.89%). There was a peak incidence in age of 55–60 years group, and a lower incidence in who lived in plain group compared with suburban, mountain and seashore group. 3380 cases of HPV positive sample were genotyped, 11.01% (372/3380) cases could not be classified, among the typed 3008 cases, 101 cases were identified without HR-HPV type infection, 2907 cases were infected with one HR-HPV type at least, the 6 most common HR-HPV types in descending order of infection, were type 52 (33.4%, 16 (20.95%), 58 (15.93%), 33 (9.94%), 68 (9.22%) and 18 (8.36%). The combined prevalence of HPV types 16 and 18 accounted for 28.52% of total infection. However, type 52 plus 58 presented 48.23% of total infection. 2209/2907 cases were infected with a single HPV type and 698/2907 cases were infected with multiple types, and multiple infection constituent ratio increased with age, with a peak incidence in age 55–60 years group. Conclusions Our findings showed low prevalence of HPV vaccine types (16 and 18) and relatively high prevalence of HPV-52 and -58, support the hypothesis that the second-generation HPV vaccines including HPV-52 and -58 may offer higher protection for women in rural Guangdong Province.
Databáze: OpenAIRE
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