A comparison of responses to intravitreal bevacizumab, ranibizumab, or aflibercept injections for neovascular age-related macular degeneration
| Autor: | Hae Jung Sun, Sung Jin Lee, Dae Hyun Park |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Visual acuity genetic structures Bevacizumab Fundus Oculi Recombinant Fusion Proteins Visual Acuity Angiogenesis Inhibitors 03 medical and health sciences 0302 clinical medicine Ranibizumab Age related Ophthalmology medicine Humans Macula Lutea Fluorescein Angiography Intravitreal bevacizumab Aged Retrospective Studies Aflibercept Dose-Response Relationship Drug business.industry Macular degeneration medicine.disease eye diseases Receptors Vascular Endothelial Growth Factor Treatment Outcome 030104 developmental biology Intravitreal Injections Wet Macular Degeneration 030221 ophthalmology & optometry Female sense organs medicine.symptom business Tomography Optical Coherence After treatment Follow-Up Studies medicine.drug |
| Zdroj: | International Ophthalmology. 37:1205-1214 |
| ISSN: | 1573-2630 0165-5701 |
| DOI: | 10.1007/s10792-016-0391-4 |
| Popis: | To compare the responses of intravitreal injections of bevacizumab, ranibizumab, or aflibercept for the treatment of neovascular age-related macular degeneration (nAMD). This retrospective study examined 232 eyes of 232 patients who received intravitreal anti-vascular endothelial growth factor (VEGF) injections due to treatment-naive nAMD. All patients, who were followed-up for at least 1 year, were treated with intravitreal injections monthly until 3 months, and then as needed. We evaluated the effects of intravitreal injections for treatment of nAMD using the central macular thickness (CMT), subretinal fluid (SRF), pigment epithelial detachment (PED) size, and best-corrected visual acuity (BCVA). CMT, SRF, PED size, and BCVA (LogMAR) were significantly decreased after treatment with all three anti-VEGF agents. Overall, the bevacizumab, ranibizumab, and aflibercept treatments showed no significant differences in their responses. However, the aflibercept injections decreased PED size more quickly than bevacizumab injections (P = 0.034). Bevacizumab, ranibizumab, and aflibercept injections are effective treatments for nAMD and have similar responses, although the number of injections of aflibercept was fewer than other anti-VEGF agents. In addition, aflibercept injections may be a better choice than other anti-VEGF agents for cases of severe increases in PED height. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink