Afferent facilitation of corticomotor responses is increased by IgGs of patients with NMDA-receptor antibodies
| Autor: | Véronique Rogemond, Jérôme Honnorat, Adrien Didelot, Mario Manto, Josep Dalmau |
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| Rok vydání: | 2010 |
| Předmět: |
animal structures
Stimulation Receptors N-Methyl-D-Aspartate Article H-Reflex Forelimb medicine Animals Humans Rats Wistar Muscle Skeletal Autoantibodies Afferent Pathways integumentary system business.industry Motor Cortex Glutamate receptor Evoked Potentials Motor Spinal cord Electric Stimulation Rats body regions medicine.anatomical_structure Spinal Cord nervous system Neurology Immunoglobulin G Facilitation NMDA receptor Neurology (clinical) H-reflex business Neuroscience Motor cortex |
| Zdroj: | Journal of Neurology. 258:27-33 |
| ISSN: | 1432-1459 0340-5354 |
| DOI: | 10.1007/s00415-010-5674-5 |
| Popis: | A severe subacute encephalitis associated with auto-antibodies to the NMDA receptor (NMDA-R) has been reported in humans. These antibodies are directed to NR1/NR2 heteromers of the NMDA receptor. We studied the effects of patients’ cerebrospinal fluid (CSF) injected in rFr2 (the prefrontal area) on the afferent facilitation in a conditioning paradigm for corticomotor responses. The afferent facilitation was assessed in forelimbs and hind-limbs of rats, before and after application of trains of high-frequency stimulation (HFS) which are known to modulate the excitability of M1. Before HFS, patients’ CSF did not modify afferent facilitation. After HFS, the amplitudes of corticomotor responses before conditioning were significantly larger in forelimbs and hindlimbs. There was an increase of the afferent facilitation in forelimbs. The same effect was observed after injection of purified IgGs from patients’ sera. Our results highlight that IgGs of patients with NMDA-R antibodies induce a state of corticomotor hyperexcitability following application of HFS over the prefrontal area. |
| Databáze: | OpenAIRE |
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