Preliminary report on plasma homocysteine and hormonal variations in infertile women in Lagos, Nigeria
| Autor: | Christian Chigozie Makwe, V O Osunkalu, Oluwatosin J Akinsola, Adediran Adewumi, Oluseun Funke Akomolafe |
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| Rok vydání: | 2015 |
| Předmět: |
Infertility
lcsh:R5-920 medicine.medical_specialty Hyperhomocysteinemia Homocysteine business.industry Female infertility Nigeria homocysteine medicine.disease hormone parameters Prolactin chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Plasma homocysteine Female infertility lcsh:Medicine (General) business Luteinizing hormone Hormone |
| Zdroj: | Journal of Clinical Sciences, Vol 12, Iss 1, Pp 14-19 (2015) |
| ISSN: | 2408-7408 |
| DOI: | 10.4103/1595-9587.160761 |
| Popis: | Background: The relationship between infertility and hormonal variations has been variously documented, but little has been reported on the interactions between hormonal factors, homocysteine (Hcy), and female infertility. Objective: This study aimed to evaluate the relationship between plasma Hcy levels and hormonal variations in infertile women. Materials and Methods: This descriptive cross-sectional study was carried out among eligible infertile and fertile women seeking care at the Lagos University Teaching Hospital, Lagos, Nigeria. The subjects were 100 women referred for management of infertility, and the controls were 50 fertile women who had given birth within the past year. Fasting plasma levels of Hcy were estimated using enzyme immunoassay. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, prolactin, and progesterone were measured using Access 2 (Immunoassay systems-beckman coulter, inc.250S.Kraemer blvd.Brea, ca 92821. U.S.A). Results: Mean plasma Hcy levels for subjects and controls were 9.50 ± 1.88 μmol/L and 9.44 ± 1.85 μmol/L, respectively, with no significant variation (P = 0.952). Plasma Hcy was not significantly associated with infertility and hormone levels. The mean serum levels of LH, FSH, and prolactin were significantly higher among subjects compared to controls. Conclusion: Hormonal variations observed in infertile women did not appear to significantly alter plasma Hcy levels, and hyperhomocysteinemia (HHcy) may not have significantly contributed to female infertility in our environment. |
| Databáze: | OpenAIRE |
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