Muse cells and induced pluripotent stem cell: implication of the elite model
| Autor: | Masaaki Kitada, Shohei Wakao, Mari Dezawa |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pluripotent Stem Cells
Cell type Somatic cell Cellular differentiation Induced Pluripotent Stem Cells Population Elite model Kruppel-Like Transcription Factors Review Biology Models Biological Cell Line Proto-Oncogene Proteins c-myc Kruppel-Like Factor 4 Mice Cellular and Molecular Neuroscience SOX2 Animals Humans Induced pluripotent stem cell education Molecular Biology Adult stem cells Genetics Pharmacology Tumorigenicity education.field_of_study SOXB1 Transcription Factors Mesenchymal stem cell Cell Differentiation Mesenchymal Stem Cells Cell Biology Fibroblasts Stochastic model Molecular Medicine Octamer Transcription Factor-3 Neuroscience Adult stem cell |
| Zdroj: | Cellular and Molecular Life Sciences |
| ISSN: | 1420-682X |
| DOI: | 10.1007/s00018-012-0994-5 |
| Popis: | Induced pluripotent stem (iPS) cells have attracted a great deal attention as a new pluripotent stem cell type that can be generated from somatic cells, such as fibroblasts, by introducing the transcription factors Oct3/4, Sox2, Klf4, and c-Myc. The mechanism of generation, however, is not fully understood. Two mechanistic theories have been proposed; the stochastic model purports that every cell type has the potential to be reprogrammed to become an iPS cell and the elite model proposes that iPS cell generation occurs only from a subset of cells. Some reports have provided theoretical support for the stochastic model, but a recent publication demonstrated findings that support the elite model, and thus the mechanism of iPS cell generation remains under debate. To enhance our understanding of iPS cells, it is necessary to clarify the properties of the original cell source, i.e., the components of the original populations and the potential of each population to become iPS cells. In this review, we discuss the two theories and their implications in iPS cell research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|