Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells

Autor: Carly Lewis, Cathy Chen, Elva Dίaz, Jan A. Nolta, Noriko Satake, Kit S. Lam, Gustavo A. Barisone, Connie P.M. Duong
Rok vydání: 2015
Předmět:
Proliferation
Cell
Apoptosis
Stem Cell Research - Nonembryonic - Human
Leukocytes
2.1 Biological and endogenous factors
Aetiology
Cancer
Pediatric
Tumor
Chemistry
Hematology
Gene Expression Regulation
Neoplastic
Haematopoiesis
medicine.anatomical_structure
Molecular Medicine
Stem cell
Pediatric Cancer
Childhood Leukemia
1.1 Normal biological development and functioning
Mononuclear
Clinical Sciences
Immunology
Bone Marrow Cells
Peripheral blood mononuclear cell
Article
Cell Line
Rare Diseases
Underpinning research
MXD3
Cell Line
Tumor
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Genetics
medicine
Humans
B Acute Lymphoblastic Leukemia
Molecular Biology
Neoplastic
Precursor B acute lymphoblastic leukemia
Cell Cycle Checkpoints
Cell Biology
Stem Cell Research
Hematopoietic Stem Cells
Repressor Proteins
Orphan Drug
Gene Expression Regulation
Cell culture
Case-Control Studies
Leukocytes
Mononuclear
Cancer research
Generic health relevance
Bone marrow
Medulloblastoma
Zdroj: Blood cells, molecules & diseases, vol 54, iss 4
ISSN: 1079-9796
Popis: MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.
Databáze: OpenAIRE
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