Brain Translation: A Feather Tips the Scale
| Autor: | Dmytro Ustianenko, Chaolin Zhang, Melissa G. McKenzie |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cell
Biology 03 medical and health sciences Exon chemistry.chemical_compound 0302 clinical medicine Eukaryotic translation Cognition Protein biosynthesis medicine Animals Autistic Disorder Molecular Biology 030304 developmental biology 0303 health sciences EIF4G Brain Translation (biology) Cell Biology Feathers Synaptic protein Cell biology medicine.anatomical_structure chemistry Cytoplasmic ribonucleoprotein granule Eukaryotic Initiation Factor-4G 030217 neurology & neurosurgery |
| Zdroj: | Molecular cell. 77(6) |
| ISSN: | 1097-4164 |
| Popis: | In this issue of Molecular Cell, Gonatopoulos-Pournatzis et al. (2020) report a neuron-specific microexon in eIF4G translation initiation factors that dampens synaptic protein translation. Autism-associated disruption of this exon results in increased protein production, likely through reduced coalescence with cytoplasmic ribonucleoprotein granule components, including FMRP. |
| Databáze: | OpenAIRE |
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