Copper(ii) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells
| Autor: | Vladimir B. Arion, Éva A. Enyedy, Denisa Darvasiová, Sergiu Shova, Maria V. Babak, Kateryna Ohui, Jia Min Lim, Wee Han Ang, Oleg Palamarciuc, Peter Rapta, Angela Sîrbu |
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| Rok vydání: | 2017 |
| Předmět: |
Models
Molecular Thiosemicarbazones Stereochemistry NF-E2-Related Factor 2 Sodium Intracellular Space Molecular Conformation chemistry.chemical_element Breast Neoplasms 010402 general chemistry 01 natural sciences Redox Medicinal chemistry Antioxidants Inorganic Chemistry chemistry.chemical_compound Electrochemistry Organometallic Compounds Humans Cytotoxicity Semicarbazone Cell Proliferation Aqueous solution 010405 organic chemistry Water Copper 0104 chemical sciences chemistry Cell culture Drug Resistance Neoplasm Proton NMR Reactive Oxygen Species |
| Zdroj: | Dalton transactions (Cambridge, England : 2003). 46(12) |
| ISSN: | 1477-9234 |
| Popis: | A series of water-soluble sodium salts of 3-formyl-4-hydroxybenzenesulfonic acid thiosemicarbazones (or sodium 5-sulfonate-salicylaldehyde thiosemicarbazones) containing different substituents at the terminal nitrogen atom (H, Me, Et, Ph) and their copper(II) complexes have been prepared and characterised by elemental analysis, spectroscopic techniques (IR, UV-vis, 1H NMR), ESI mass spectrometry, X-ray crystallography and cyclic voltammetry. The proligands and their copper(II) complexes exhibit moderate water solubility and good stability in aqueous environment, determined by investigating their proton dissociation and complex formation equilibria. The copper(II) complexes showed moderate anticancer activity in established human cancer cell lines, while the proligands were devoid of cytotoxicity. The anticancer activity of the copper(II) complexes correlates with their ability to induce ROS accumulation in cells, consistent with their redox potentials within the biological window, triggering the activation of antioxidation defense mechanisms in response to the ROS insult. These studies pave the way for the investigation of ROS-inducing copper(II) complexes as prospective antiproliferative agents in cancer chemotherapy. |
| Databáze: | OpenAIRE |
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