Do cultures contribute to optimisation of antibiotic therapy in the intensive care unit?
| Autor: | M Hoitsma, I.M. Hoepelman, Marc J. M. Bonten, C A M Schurink, Jos Joore, M Rozenberg-Arska |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty medicine.drug_class Antibiotics law.invention law Intensive care medicine Humans Pharmacology (medical) Respiratory system Intensive care medicine Respiratory Tract Infections Antibacterial agent Bacteriological Techniques Bacteria Respiratory tract infections business.industry Bacterial Infections General Medicine Middle Aged Antimicrobial Intensive care unit Anti-Bacterial Agents Culture Media Intensive Care Units Infectious Diseases medicine.anatomical_structure Female business Respiratory tract |
| Zdroj: | International Journal of Antimicrobial Agents. 23:325-331 |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2003.08.013 |
| Popis: | Obtaining diagnostic microbiological cultures before initiating empirical antimicrobial therapy is part of the diagnostic work-up of intensive care patients with a clinical suspicion of infection. However, it is unknown to what extent these cultures provide a microbiological cause of infection and to what extent antimicrobial therapy is influenced. During a 6-month period, all episodes of suspected clinical infection were analysed and categorised as non-microbiologically proven infection (non-MPI) or MPI. Effects of culture results on antibiotic therapy were analysed for episodes of respiratory tract infection. Invasive diagnostic techniques were not routinely used for diagnosis of respiratory tract infections. Among 212 patients admitted, 147 episodes of clinical suspicion of infection were recorded (104 for respiratory tract infection) and 1147 microbiological cultures were obtained (0.64 culture per patient day). Antibiotics were administered on 1111 (62%) of 1803 patients days. Of the respiratory tract infections, 571 cultures resulted in 49 (47%) MPI. Cover with empirical antibiotics was inappropriate in 7 of 104 cases (8%) of respiratory infections. In 12 cases (11.5%) empirical therapy could have been changed based on culture results. Negative cultures were never followed by cessation of therapy, but the duration of treatment was significantly shorter for non-MPI. Forty-seven percent of respiratory tract infections were microbiologically confirmed and, based on culture results, empirical antimicrobial therapy could have been influenced in 11.5% of cases of respiratory tract infections. These findings provide aspects to evaluate and improve the diagnostic work-up of infections in the ICU. |
| Databáze: | OpenAIRE |
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