A Phase II Trial of Sequential MTx and 5-FU Alternated with 4-Epidoxorubicin and Cisplatin in Advanced Gastric Cancer
| Autor: | B. G. Taal, W.W. ten Bokkel Huinink, H. R. Franklin, J. G. McVie, G. Simonetti |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Adolescent Gastric adenocarcinoma Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Severe toxicity Aged Epirubicin Cisplatin business.industry Combination chemotherapy General Medicine Middle Aged Advanced gastric cancer Prognosis Methotrexate Doxorubicin Female Fluorouracil business medicine.drug |
| Zdroj: | Cancer Investigation. 8:501-504 |
| ISSN: | 1532-4192 0735-7907 |
| Popis: | Twenty-one patients with advanced gastric adenocarcinoma were treated with a combination chemotherapy schedule of sequential methotrexate and 5-fluorouracil alternated with 4-epidoxorubicin and cisplatin. This scheme was active, with 7 partial responses leading to a response rate of 33% (± 20%). In two cases the tumor became operable. No severe toxicity developed and the treatment was usually well tolerated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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