Heterozygotes for ACAN dwarfism alleles in horses have reduced stature

Autor:	E. Bailey, K. T. Graves, J. E. Eberth
Rok vydání:	2020
Předmět:	0301 basic medicine Heterozygote medicine.medical_specialty Withers Dwarfism Compound heterozygosity 03 medical and health sciences Decreased height Internal medicine biology.animal Genetics medicine Animals Aggrecans Horses Allele Alleles biology Pony Significant difference 0402 animal and dairy science Heterozygote advantage 04 agricultural and veterinary sciences General Medicine medicine.disease 040201 dairy & animal science 030104 developmental biology Endocrinology Horse Diseases Animal Science and Zoology
Zdroj:	Animal Genetics. 51:420-422
ISSN:	1365-2052 0268-9146
DOI:	10.1111/age.12921
Popis:	Homozygous and compound heterozygous Miniature horses for ACAN alleles D1, D2, D3* and D4 exhibit chondrodysplastic dwarfism (OMIA 001271-9796). In a previous study, the carrier rate for these four alleles, combined, was 26.2%. The purpose of this study was to investigate whether carriers of these dwarfism-causing alleles had a shorter withers height than non-carriers. A total of 245 Miniature horses were tested for these four ACAN alleles and also were measured for withers height. Of these horses, 98 were carriers and 147 were non-carriers. A statistically significant difference of 1.43 inches was observed with the carriers being shorter (P = 1.72E - 11). The range of heights for the two groups overlapped, indicating that other factors, including genes, have an impact on withers height. However, the high carrier rate of these dwarfism-causing variants may be due to selection for decreased height.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e802f7c14612277f6f9bbdb00234f36 https://doi.org/10.1111/age.12921 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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