Timing considerations for removal of early cumulus cells in short-term insemination strategies
| Autor: | Xingting Chen, James M. Cummins, Zhiren Liu, Qicai Liu, Mingting Jiang, Yujia Guo, Chen Lin |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Pregnancy Rate Reproductive Techniques Assisted medicine.medical_treatment Context (language use) Reproductive technology Biology Cumulus Cell Insemination Andrology Endocrinology Ovulation Induction Pregnancy Genetics medicine Humans Sperm Injections Intracytoplasmic Molecular Biology Insemination Artificial Retrospective Studies Assisted reproductive technology Cumulus Cells Pronucleus Embryo Transfer Sperm Term (time) Reproductive Medicine Fertilization Animal Science and Zoology Female Developmental Biology Biotechnology |
| Zdroj: | Reproduction, fertility, and development. 33(18) |
| ISSN: | 1031-3613 |
| Popis: | Context The timing of early cumulus cell removal (ECCR) can be changed within a range. The change has an effect on the multiple pronuclei (MPN) rate and the exposure time of oocytes to sperm waste products. The timing of ECCR effects the outcomes of assisted reproductive technology, however, it is still unclear what time is best for ECCR. Aims To find the best time for ECCR based on clinical outcomes in order to increase the success rate of assisted reproductive technology. Methods A retrospective study was performed. Cycles were categorised into six groups according to the timing of ECCR. The clinical outcomes of these six groups were compared by Kruskal–Wallis test and Pearson X 2 test. Key results The timing of ECCR had a significant effect on the MPN rate, 0PN without cleavage rate and grade 1–2 embryo rate at Day 3. Among our six time groups of ECCR, the cumulus cell removal ≤4 h post-insemination group had the highest MPN rate and grade 1–2 embryo rate at Day 3, and the 5.5 h |
| Databáze: | OpenAIRE |
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