Evaluation of a Once-a-Day Theophylline Preparation in Asthmatic Children
| Autor: | Keh-Gong Wu, Yun-Ray Chang, Ren-Bin Tang, Betau Hwang, Ting Chao |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Evening medicine.drug_class medicine.medical_treatment Drug Administration Schedule Theophylline Bronchodilator medicine Humans Immunology and Allergy Dosing Child Asthma Chemotherapy business.industry Respiratory disease medicine.disease El Niño Delayed-Action Preparations Anesthesia Pediatrics Perinatology and Child Health Female business medicine.drug |
| Zdroj: | Journal of Asthma. 29:273-280 |
| ISSN: | 1532-4303 0277-0903 |
| Popis: | We conducted a study to evaluate the serum theophylline concentrations and dose interval of Theolan preparation in asthmatic children. A series of serum theophylline levels were measured both in 10 asthmatic children taking Theolan once a day and 9 children twice a day. In the once-a-day group, the peak serum theophylline level was greater than 20 micrograms/ml; whereas, in the twice-a-day group, it was mostly between 10 and 20 micrograms/ml. The difference of the peak-to-trough was more fluctuant in the once-a-day group than in the twice-a-day group. These results suggest that Theolan given once a day in the evening can be useful in the management of nocturnal asthma; however, it was difficult for once-a-day administration of Theolan to sustain rigid therapeutic serum theophylline levels. Because of rapid metabolism in children, they may require a more frequent interval than once-a-day dosing to suppress the symptoms of chronic asthma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|