Elevated plasma abscisic acid is associated with asymptomatic falciparum malaria and with IgG-/caspase-1-dependent immunity in Plasmodium yoelii-infected mice

Autor: L. Garry Adams, Elizabeth K.K. Glennon, Isaac Ssewanyana, Liusheng Huang, Shirley Luckhart, Fran Aweeka, Brandi K. Torrevillas, Dewi Megawati, Bryan Greenhouse
Rok vydání: 2018
Předmět:
0301 basic medicine
lcsh:Medicine
Parasitemia
Mice
Plant Growth Regulators
2.1 Biological and endogenous factors
2.2 Factors relating to the physical environment
Uganda
Aetiology
lcsh:Science
Child
Mice
Knockout
Multidisciplinary
biology
Caspase 1
food and beverages
medicine.anatomical_structure
Infectious Diseases
Child
Preschool
Knockout mouse
Infection
Plasmodium yoelii
Knockout
Plasmodium falciparum
Spleen
Vaccine Related
03 medical and health sciences
Rare Diseases
Immunity
parasitic diseases
medicine
Animals
Humans
Preschool
Innate immune system
Animal
organic chemicals
Prevention
lcsh:R
fungi
biology.organism_classification
medicine.disease
Malaria
Vector-Borne Diseases
Disease Models
Animal
030104 developmental biology
Good Health and Well Being
Blood chemistry
Immunoglobulin G
Immunology
Disease Models
Asymptomatic Diseases
lcsh:Q
Acids
Abscisic Acid
Zdroj: Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
ISSN: 2045-2322
Popis: Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation. Previously, we showed that oral supplementation with ABA decreased parasitemia in a mouse model of malaria, decreased liver and spleen pathology and reduced parasite transmission to mosquitoes. Here, we report that higher circulating ABA levels were associated with a reduced risk of symptomatic malaria in a cohort of Plasmodium falciparum-infected Ugandan children. To understand possible mechanisms of ABA protection in malaria, we returned to our mouse model to show that ABA effects on Plasmodium yoelii 17XNL infection were accompanied by minimal effects on complete blood count and blood chemistry analytes, suggesting a benefit to host health. In addition, orally delivered ABA induced patterns of gene expression in mouse liver and spleen that suggested enhancement of host anti-parasite defenses. To test these inferences, we utilized passive immunization and knockout mice to demonstrate that ABA supplementation increases circulating levels of protective, parasite-specific IgG and requires caspase-1 to reduce parasitemia. Collectively, ABA induces host responses that ameliorate infection and disease in an animal model and suggest that further studies of ABA in the context of human malaria are warranted.
Databáze: OpenAIRE
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