Anxiety response and restraint-induced stress differentially affect ethanol intake in female adolescent rats

Autor: María Belén Acevedo, María Carolina Fabio, Ricardo Marcos Pautassi, Macarena Soledad Fernández
Rok vydání: 2016
Předmět:
STRESS
Self Administration
Alcohol
Anxiety
chemistry.chemical_compound
Basal (phylogenetics)
0302 clinical medicine
ADOLESCENTS
ANXIETY
Sexual Maturation
General Neuroscience
Amygdala
ETHANOL INTAKE
Medicina Básica
Female
Analysis of variance
medicine.symptom
Psychology
Proto-Oncogene Proteins c-fos
Personality
Restraint
Physical
medicine.medical_specialty
Elevated plus maze
CIENCIAS MÉDICAS Y DE LA SALUD
Alcohol Drinking
Inmunología
Affect (psychology)
03 medical and health sciences
Internal medicine
medicine
Animals
Genetic Predisposition to Disease
Rats
Wistar
Psychiatry
Ethanol
Arcuate Nucleus of Hypothalamus
Central Nervous System Depressants
medicine.disease
Comorbidity
030227 psychiatry
FOS INMUNOREACTIVITY
Disease Models
Animal
Endocrinology
chemistry
Multivariate Analysis
Stress
Psychological
030217 neurology & neurosurgery
Paraventricular Hypothalamic Nucleus
Zdroj: Neuroscience. 334:259-274
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2016.08.011
Popis: Anxiety disorders are more likely to occur in women than in men, usually emerge during adolescence and exhibit high comorbidity with alcohol use disorders. Adolescents with high levels of anxiety or heightened reactivity to stress may be at-risk for developing alcohol use disorders. An approach to analyze if high levels of inborn anxiety predict greater ethanol drinking is to assess the latter variable in subjects classified as high- or low- anxiety responders. The present study assessed ethanol drinking in adolescent, female Wistar, rats classified as high-, low- or average-anxiety responders and exposed or not to restraint stress (RS, Exp. 1). Classification was made through a multivariate index derived from testing anxiety responses in an elevated plus maze and a light-dark box tests. RS was applied after animals had been initiated to ethanol drinking. Intake of sweetened ethanol was unaffected by level of anxiety response. Adolescents with high levels of inborn anxiety exhibited significantly higher intake of unsweetened ethanol than counterparts with standard levels of anxiety, yet this effect was inhibited by RS exposure. Experiment 2 assessed FOS immunoreactivity after RS. Stress induced a significant increase in FOS immunoreactivity at the paraventricular nucleus, yet this effect was unaffected by level of anxiety response. Female adolescents with high levels of basal anxiety may be at-risk for exhibiting increased predisposition for ethanol intake and preference. The study also indicates that stress may exert differential effects on adolescent ethanol intake as a function of the level of anxiety response. Fil: Acevedo, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina Fil: Fabio, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina Fil: Fernandez, Macarena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Databáze: OpenAIRE
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