Brain metastasis DNA methylomes, a novel resource for the identification of biological and clinical features
Autor: | Diego M. Marzese, James S. Wilmott, Javier I. J. Orozco, Richard A. Scolyer, Charles Cobbs, Matthew P. Salomon, Dave S.B. Hoon, Parvinder Hothi, Ayla O. Manughian-Peter |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Statistics and Probability Adult Epigenomics Male Data Descriptor Library and Information Sciences Education Metastasis 03 medical and health sciences Breast cancer Medicine Sequencing Humans Epigenetics Neoplasm Metastasis Lung cancer DNA methylation business.industry Brain Neoplasms Cancer High-Throughput Nucleotide Sequencing DNA Neoplasm Sequence Analysis DNA Middle Aged medicine.disease 3. Good health Computer Science Applications CNS cancer 030104 developmental biology Cutaneous melanoma Cancer research Female Statistics Probability and Uncertainty business Information Systems Brain metastasis |
Zdroj: | Scientific Data |
ISSN: | 2052-4463 |
Popis: | Brain metastases (BM) are one the most lethal and poorly managed clinical complications in cancer patients. These secondary tumors represent the most common intracranial neoplasm in adults, most frequently originating from lung cancer, breast cancer, and cutaneous melanoma. In primary brain tumors, such as gliomas, recent advances in DNA methylation profiling have allowed for a comprehensive molecular classification. Such data provide prognostic information, in addition to helping predict patient response to specific systemic therapies. However, epigenetic alterations of metastatic brain tumors with specific biological and translational relevance still require much further exploration. Using the widely employed Illumina Infinium HumanMethylation 450K platform, we have generated a cohort of genome-wide DNA methylomes from ninety-six needle-dissected BM specimens from patients with lung cancer, breast cancer, and cutaneous melanoma with clinical, pathological, and demographic annotations. This resource offers an unprecedented and unique opportunity to identify novel DNA methylation features influencing the behavior of brain metastasis, and thus accelerate the discovery of BM-specific theranostic epigenetic alterations. |
Databáze: | OpenAIRE |
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