Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease

Autor: Anna Paterlini, Roberta Ghidoni, Marcella Catania, Mario Rosario Buffelli, Valeria Pontelli, Gianluigi Zanusso, Erika Lorenzetto, Giuliano Binetti, Mirta Borin, Giuseppe Di Fede, Simone Zorzan, Anna Avesani, Silvia Bolognin, Claudia Saraceno, Silvia Fostinelli, Luisa Benussi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
rac1 GTP-Binding Protein
Dendritic spine
Regulator
Hippocampus
lcsh:RC346-429
Alzheimer ’s disease
Mice
Neuroblastoma
0302 clinical medicine
Rho-GTPases
Amyloid precursor protein
Phosphorylation
Cells
Cultured
dendritic spine loss
Aged
80 and over
Neurons
therapeutic target
Cell biology
medicine.anatomical_structure
Fatty Acids
Unsaturated
Rac1
Transgene
Dendritic Spines
RAC1
Mice
Transgenic
tau Proteins
Biology
Pathology and Forensic Medicine
03 medical and health sciences
Cellular and Molecular Neuroscience
Alzheimer Disease
medicine
Presenilin-1
Animals
Humans
lcsh:Neurology. Diseases of the nervous system
Aged
Amyloid beta-Peptides
Research
Embryo
Mammalian
Mice
Inbred C57BL
Disease Models
Animal
030104 developmental biology
Gene Expression Regulation
Cytoplasm
biology.protein
Neurology (clinical)
Cognition Disorders
Nucleus
030217 neurology & neurosurgery
Zdroj: Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Popis: One of the earliest pathological features characterizing Alzheimer’s disease (AD) is the loss of dendritic spines. Among the many factors potentially mediating this loss of neuronal connectivity, the contribution of Rho-GTPases is of particular interest. This family of proteins has been known for years as a key regulator of actin cytoskeleton remodeling. More recent insights have indicated how its complex signaling might be triggered also in pathological conditions. Here, we showed that the Rho-GTPase family member Rac1 levels decreased in the frontal cortex of AD patients compared to non-demented controls. Also, Rac1 increased in plasma samples of AD patients with Mini-Mental State Examination
Databáze: OpenAIRE
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