Association between Genetic Variants in
| Autor: | Marcial Francis Galera, Bethânia F.R. Ribeiro, Fernanda Sales Luiz Vianna, Isabella F. Carvalho, Ana Cláudia Pereira Terças-Trettel, Lavinia Schuler-Faccini, Maria Denise Fernandes Carvalho de Andrade, Juliana Herrero da Silva, Thalita M. de Oliveira, Julia do Amaral Gomes, Juliano André Boquett, Eduarda Sgarioni |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Microcephaly genetic polymorphism teratogens lcsh:QR1-502 Nitric Oxide Synthase Type II Gastroenterology lcsh:Microbiology Zika virus 0302 clinical medicine Pregnancy Genotype Medicine Pregnancy Complications Infectious congenital abnormalities biology Zika Virus Infection Infectious Diseases In utero 030220 oncology & carcinogenesis Female Brazil Adult medicine.medical_specialty Article 03 medical and health sciences Young Adult Virology Internal medicine maternal exposure Genetic variation Humans Genetic Predisposition to Disease Allele Alleles Polymorphism Genetic business.industry Tumor Necrosis Factor-alpha Haplotype Genetic Variation Infant disease susceptibility Zika Virus biology.organism_classification medicine.disease Teratology Pregnancy Trimester First 030104 developmental biology inflammation Case-Control Studies business |
| Zdroj: | Viruses, Vol 13, Iss 325, p 325 (2021) Viruses Volume 13 Issue 2 |
| ISSN: | 1999-4915 |
| Popis: | Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in utero exposed to ZIKV infection, but born without congenital anomalies, were evaluated. Children with CZS were predominantly infected by ZIKV in the first trimester (p < 0.001) and had mothers with lower educational level (p < 0.001) and family income (p < 0.001). We found higher risk of CZS due the allele rs2297518[A] of NOS2 (OR = 2.28, CI 95% 1.17–4.50, p = 0.015). T allele and TT/CT genotypes of the TNF rs1799724 and haplotypes associated with higher expression of TNF were more prevalent in children with CZS and severe microcephaly (p = 0.029, p = 0.041 and p = 0.030, respectively). Our findings showed higher risk of CZS due ZIKV infection in the first trimester and suggested that polymorphisms in NOS2 and TNF genes affect the risk of CZS and severe microcephaly. |
| Databáze: | OpenAIRE |
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