Contribution of adverse drug reactions to hospital admission of older patients
| Autor: | T.J.M. van der Cammen, C. K. Mannesse, A. J. Man In 'T Veld, Frans H.M. Derkx, M A de Ridder |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Aging medicine.medical_specialty Gastrointestinal bleeding Pediatrics Drug-Related Side Effects and Adverse Reactions Cross-sectional study Frail Elderly Hospitals University Patient Admission Older patients Risk Factors Internal medicine medicine Adverse Drug Reaction Reporting Systems Humans Drug Interactions Aged Netherlands Aged 80 and over business.industry General Medicine Odds ratio medicine.disease Confidence interval Cross-Sectional Studies Hospital admission Accidental Falls Female Observational study Geriatrics and Gerontology business Algorithms Adverse drug reaction |
| Zdroj: | Age and Ageing. 29:35-39 |
| ISSN: | 1468-2834 |
| Popis: | Objective: to describe the severity of adverse drug reactions as a factor in hospital admission of older patients, and to identify risk indicators for severe adverse drug reactions in these patients. Design: observational cross-sectional study. Setting: Five wards in a university hospital in the Netherlands. Subjects: patients aged 70 and over admitted to general medical wards. Methods: use of statistical comparison and Kramer’s algorithm. Results: a severe adverse drug reaction was present in 25 (24%) of 106 patients. Thirteen patients (12%; 95% confidence interval 6.1‐18.6%) were admitted probably because of an adverse drug reaction. Risk indicators for a severe adverse drug reaction were a fall before admission (odds ratio 51.3, P o 0:006), gastrointestinal bleeding or haematuria (odds ratio 19.8, P < 0.001) and the use of three or more drugs (odds ratio 9.8, P o 0:04). Conclusion: adverse drug reactions are an important cause of hospital admissions in older people. A fall before admission may indicate a severe adverse drug reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|