Alterations in circulating estradiol-17-beta in male patients with Graves's disease
| Autor: | Usha Chopra, Inder J. Chopra, William D. Odell, Guy E. Abraham, David H. Solomon |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Adolescent Radioimmunoassay Disease Internal medicine medicine Effective treatment Humans Child Aged Estradiol business.industry General Medicine Luteinizing Hormone Middle Aged medicine.disease Graves Disease Long-Acting Thyroid Stimulator Thyroxine Long acting Endocrinology Gynecomastia Male patient Propylthiouracil Follicle Stimulating Hormone business hormones hormone substitutes and hormone antagonists Hormone medicine.drug |
| Zdroj: | The New England journal of medicine. 286(3) |
| ISSN: | 0028-4793 |
| Popis: | Serum concentrations of estradiol-17β (E2), gonadotropins and long acting thyroid stimulator were studied in 10 consecutive male patients with active Graves's disease. Serum E2 was elevated in all patients before therapy. In two men with gynecomastia the concentrations were as high as those observed in normal women. The per cent dialyzable E2 was significantly reduced in hyperthyroid males as compared to normal males and was similar to that seen in eugonadal women; but the absolute concentration of unbound E2, evaluated in one prepubertal and five adult patients without gynecomastia, was elevated in four of the five adults. The mean serum concentrations of luteinizing and follicle-stimulating hormones were also higher in the hyperthyroid men than in normal men. Serum E2 fell gradually and consistently during effective treatment of hyperthyroidism with propylthiouracil. Neither the occurrence of gynecomastia nor the serum concentration of E2 correlated with serum concentration of long acting thyro... |
| Databáze: | OpenAIRE |
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