Correction of Experimental Retinal Ischemia by l-Isomer of Ethylmethylhydroxypyridine Malate
Autor: | Anna A. Peresypkina, M. V. Korokin, Anton L. Pazhinsky, M. V. Pokrovskii, Evgenya Beskhmelnitsyna, Anna S. Pobeda |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Intraocular pressure
medicine.medical_specialty Physiology Emoxipine Clinical Biochemistry l-isomer of ethylmethylhydroxypyridine malate Biochemistry Article Ophthalmoscopy 03 medical and health sciences Mechanical pressure chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine cardiovascular diseases Molecular Biology Retina medicine.diagnostic_test Retinal ischemia lcsh:RM1-950 retinal ischemia Retinal Cell Biology b/a coefficient Wistar rats Electrophysiology medicine.anatomical_structure lcsh:Therapeutics. Pharmacology chemistry 030221 ophthalmology & optometry 030217 neurology & neurosurgery Electroretinography |
Zdroj: | Antioxidants, Vol 8, Iss 2, p 34 (2019) Antioxidants Volume 8 Issue 2 |
ISSN: | 2076-3921 |
Popis: | An important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative&ndash l-isomer of ethylmethylhydroxypyridine malate. A modification to the retinal ischemia-reperfusion model was used, in which an increase in intraocular pressure is carried out by mechanical pressure (110 mmHg) to the front chamber of the eye for 30 min. The protective effects of l-isomer of ethylmethylhydroxypyridine malate in comparison with Emoxipine as pretreatment, with parabulbar injection, based on the model of retinal ischemia-reperfusion, were estimated by the changes in the ratio of the amplitudes of the a- and b-waves of electroretinography (the b/a coefficient) and ophthalmoscopy. The use of l-isomer of ethylmethylhydroxypyridine malate improves the retinal electrophysiological state after 72 h of reperfusion in the group of rats treated with l-isomer of ethylmethylhydroxypyridine malate, the coefficient b/a was reliably increased by 9.5%, p < 0.05, in comparison with animals treated with Emoxipine, and by 91.7%, p < 0.05, in comparison with the group with no treatment. Furthermore, it prevents the development of ischemic changes in the retina observed in ophthalmoscopy to a greater extent than Emoxipine. |
Databáze: | OpenAIRE |
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