Co‐occurrence of IgE and IgG autoantibodies in patients with chronic spontaneous urticaria
| Autor: | Maurizio Lorini, Silvia Ferrucci, Riccardo Asero, V. Carbonelli, Massimo Cugno, Angelo V. Marzano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Immunology Omalizumab Immunoglobulin E medicine.disease_cause Basophil degranulation Autoantigens Thyroglobulin Thromboplastin 03 medical and health sciences 0302 clinical medicine Allergen Antigen medicine Immunology and Allergy Humans Chronic Urticaria Lectins C-Type Aged Autoantibodies Aged 80 and over biology business.industry Receptors IgE Autoantibody Original Articles Middle Aged Mast cell 030104 developmental biology medicine.anatomical_structure Immunoglobulin G biology.protein Female Antibody business 030215 immunology medicine.drug |
| Zdroj: | Clin Exp Immunol |
| Popis: | Summary Chronic spontaneous urticaria (CSU) pathogenesis shows a complex and still unclear interplay between immunoglobulin (Ig)G- and IgE-mediated autoimmunity, leading to mast cell and basophil degranulation and wheal formation. The objective of this study was to evaluate at the same time IgE- and IgG-reactivity to well recognized and recently reported autoantigens in CSU patients, and to assess the effects of such reactivity on response to the anti-IgE monoclonal antibody omalizumab. Twenty CSU patients underwent omalizumab treatment. Urticaria activity score 7 (UAS7) was recorded at baseline and at different drug administration time-points for categorizing early-, late- or non-responders. At baseline, sera from the 20 patients and from 20 controls were tested for IgE and IgG autoantibodies to high- and low-affinity IgE receptors (FcεRI and FcεRII), tissue factor (TF) and thyroglobulin (TG) by immunoenzymatic methods. Antibody levels were compared with those of controls and analysed according to response. Eighteen patients were omalizumab responders (11 early and seven late), while two were non-responders. More than 50% of patients had contemporary IgE and IgG to at least to one of the four different autoantigens. Late responders showed higher levels of both anti-TF IgE and IgG than early responders (P= 0·011 and P= 0·035, respectively). Twenty-five per cent of patients had levels of anti-FcεRI IgE, exceeding the upper normal limit, suggesting that it could be a novel auto-allergen in CSU. In CSU, there is an autoimmune milieu characterized by the co-existence of IgE and IgG autoantibodies to the same antigen/allergen, particularly in late responders to omalizumab, possibly explaining the slower response. |
| Databáze: | OpenAIRE |
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