Maternal posttraumatic stress and FKBP5 Genotype interact to predict trauma-related symptoms in preschool-age offspring
| Autor: | Margaret J. Briggs-Gowan, Colin A. Hodgkinson, Destiny M.B. Printz Pereira, Damion J. Grasso, Lauren S. Wakschlag, Kimberly J. McCarthy |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Genotype
Offspring Ethnic group Mothers Article Stress Disorders Post-Traumatic Tacrolimus Binding Proteins 03 medical and health sciences 0302 clinical medicine Medicine SNP Humans Gene–environment interaction Alleles business.industry 030227 psychiatry Psychiatry and Mental health Clinical Psychology Posttraumatic stress Child Preschool Female Gene-Environment Interaction FKBP5 business 030217 neurology & neurosurgery Psychopathology Clinical psychology |
| Zdroj: | J Affect Disord |
| Popis: | Background Children of parents with posttraumatic stress (PTS) face heightened risk for developing emotional and behavioral problems, regardless of whether they experience a traumatic event themselves. The current study investigates whether child FKBP5, a stress relevant gene shown to interact with child trauma exposure to increase risk for PTS, also moderates the well-established link between maternal PTS and child symptoms. Methods Data are derived from a longitudinal lab-based study for which 205 dyads of trauma-exposed mothers and their preschool-age children from a sample enriched for violence exposure provided DNA samples and completed measures of maternal and child trauma-related symptoms. Hypotheses tested whether child FKBP5 rs1360780 SNP genotype interacts with child trauma exposure and maternal PTS to predict child trauma-related symptoms. Results Hypotheses were partially supported, with maternal PTS predicting increased child symptoms for children carrying the minor T-allele (CT/TT), but not those homozygous for the major C-allele. Limitations Study results may not generalize to lower-risk or non-clinical populations, did not assess between-group differences in race/ethnicity, and do not consider other genes that may interact with FKBP5 or contribute to genetic risk for trauma-related impairment. Conclusions These findings provide the first evidence that the robust gene x environment interaction involving FKBP5 and child trauma exposure extends to other environmental perturbations, including maternal PTS. Our results highlight the importance of efforts to address trauma-related psychopathology in caregivers, which may disrupt intergenerational risk processes and improve outcomes for children. |
| Databáze: | OpenAIRE |
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