Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria
| Autor: | Lamia Salima Seddiki, Khaled Sekkoum, Mohd Roslan Sulaiman, Nasser Belboukhari, A. Cheriti, Aminata Ould el hadj-khelil |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Serotonin Hot Temperature medicine.drug_class Analgesic Anti-Inflammatory Agents TRPV1 Pain TRPV Cation Channels Asteraceae Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Formaldehyde Drug Discovery Animals Edema Medicine Hot plate test Pain Measurement 030304 developmental biology Inflammation Pharmacology Analgesics Mice Inbred BALB C 0303 health sciences Behavior Animal Traditional medicine Plant Extracts business.industry Solutions Opioid chemistry Capsaicin Algeria 030220 oncology & carcinogenesis Medicine Traditional business Histamine medicine.drug |
| Zdroj: | Journal of Ethnopharmacology. 275:114137 |
| ISSN: | 0378-8741 |
| Popis: | Ethnopharmacological relevance Launaea arborescens, its vernacular name is Mol-albina belonging to asteracaea family origin of the southwest of Algeria. This plant is used in folk medicines to treat gastroenteritis, diabetes, child aliment and other diseases; it is taken macerated or boiled. Aim This study aims to evaluate the anti-inflammation an analgesic activity of the aqueous extract of Launaea arborescens (AqELA) and its pathway of action. Methods the investigation of anti-inflammatory and analgesic effects were done using formalin test, acetic acid test. For mechanism investigation, it was used hot plate test to induce opioid receptors, a histamine and serotonin test to induce edema paw, finally, for the TRPV1 receptor, it was used the capsaicin test. Results The aqueous extract of Launaea arborescens showed a significant inhibition of abdominal writhing test 95% and 100% inhibition of licking paw using acid acetic test and formalin test respectively (EC: 47 mg/kg and 104 mg/kg). The analgesic effect of the aqueous extract of Launaea arborescens showed inhibition of sensation of pain after 120 min compared to morphine effect. The aqueous extract of Launaea arborescens reduced paw volume after 180 min and 120 min for histamine and serotonin respectively with dose-dependent. Concerning of TRPV1 receptors, the inhibition was showed at doses 100 mg and 300 mg. Conclusion Our results contribute towards validation of the traditional use of Launaea arborescens for inflammation ailment. |
| Databáze: | OpenAIRE |
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