Regulatory T cells increase in breast cancer and in stage IV breast cancer
| Autor: | Junlan Yang, Hui Liu, Bo Yang, Shunchang Jiao, Liangliang Wu, Zhen-hong Zhou, Yi Hu, Zhikuan Wang |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A Oncology Cancer Research medicine.medical_specialty Adolescent Receptor ErbB-2 medicine.medical_treatment CD3 Immunology Breast Neoplasms T-Lymphocytes Regulatory Flow cytometry Young Adult Immune system Breast cancer Internal medicine medicine Humans Immunology and Allergy Young adult Receptor Aged Neoplasm Staging Chemotherapy medicine.diagnostic_test biology business.industry T-Lymphocytes Helper-Inducer Middle Aged medicine.disease Vascular endothelial growth factor A Health Cancer research biology.protein Female business |
| Zdroj: | Cancer Immunology, Immunotherapy. 61:911-916 |
| ISSN: | 1432-0851 0340-7004 |
| DOI: | 10.1007/s00262-011-1158-4 |
| Popis: | Expression levels of VEGF and Her-2, levels of T-regulatory (Treg) cells, levels of CD3+ cells, and ratios of Th (CD4+ T cells)/Tr (Treg) cells were compared between stage I, II, III, and IV breast cancer patients (n = 120) prior to chemotherapy and healthy women (n = 30). Cells from peripheral blood were counted by flow cytometry, Her-2 and VEGF expression was detected by pathological examination, and Her-2 was detected by FISH. Breast cancer patients had more Treg cells and a lower ratio of Th/Tr cells than the healthy women. Stage IV breast cancer patients had more Treg cells and a lower ratio of Th/Tr cells than stage I, II, or III breast cancer patients. Patients positive for VEGF had a lower ratio of Th/Tr cells compared with patients negative for VEGF, and those positive for both VEGF and Her-2 also had a lower ratio of Th/Tr cells compared with patients not positive for both VEGF and Her-2. The decreased Th/Tr cells ratio indicates impaired immune function, suggesting that the stage IV breast cancer and the Her-2/VEGF-positive breast cancer patients have lower immune function. |
| Databáze: | OpenAIRE |
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