Reduced white matter fractional anisotropy mediates cortical thickening in adults born preterm with very low birthweight
| Autor: | Kari Anne I. Evensen, Live Eikenes, Lars M. Rimol, Gro Løhaugen, Marit Martinussen, Violeta Nl Botellero, Ann-Mari Brubakk, Jon Skranes, Anastasia Yendiki, Marit S. Indredavik, Knut Jørgen Bjuland, Stian Lydersen, Asta Håberg |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cognitive Neuroscience Biology Corpus callosum Reduced white matter 050105 experimental psychology White matter 03 medical and health sciences 0302 clinical medicine Fractional anisotropy medicine Humans Infant Very Low Birth Weight 0501 psychology and cognitive sciences Gray Matter Cerebral Cortex 05 social sciences Anatomy White Matter medicine.anatomical_structure Neurology Frontal lobe Cerebral cortex Anisotropy Premature Birth Female Cortical thickening Forceps minor 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage |
| ISSN: | 1053-8119 |
| Popis: | Development of the cerebral cortex may be affected by aberrant white matter development. Preterm birth with very low birth weight (VLBW) has been associated with reduced fractional anisotropy of white matter and changes in cortical thickness and surface area. We use a new methodological approach to combine white and gray matter data and test the hypothesis that white matter injury is primary, and acts as a mediating factor for concomitant gray matter aberrations, in the developing VLBW brain. T1 and dMRI data were obtained from 47 young adults born preterm with VLBW and 73 term-born peers (mean age = 26). Cortical thickness was measured across the cortical mantle and compared between the groups, using the FreeSurfer software suite. White matter pathways were reconstructed with the TRACULA software and projected to their cortical end regions, where cortical thickness was averaged. In the VLBW group, cortical thickness was increased in anteromedial frontal, orbitofrontal, and occipital regions, and fractional anisotropy (FA) was reduced in frontal lobe pathways, indicating compromised white matter integrity. Statistical mediation analyses demonstrated that increased cortical thickness in the frontal regions was mediated by reduced FA in the corpus callosum forceps minor, consistent with the notion that white matter injury can disrupt frontal lobe cortical development. Combining statistical mediation analysis with pathway projection onto the cortical surface offers a powerful novel tool to investigate how cortical regions are differentially affected by white matter injury. © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ). |
| Databáze: | OpenAIRE |
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