A Clinico-Mycological Study on Suspected Cases of Chromoblastomycosis: Challenges in Diagnosis and Management
| Autor: | Gobinda Chatterjee, Atul Jain, Hirak Jyoti Raj, Prasanta Kumar Maiti, Banashree Majumdar |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Antifungal
Dermatology Section medicine.medical_specialty medicine.drug_class Clinical Biochemistry lcsh:Medicine Cladosporium carrionii medicine sclerotic bodies Chromoblastomycosis biology business.industry Lupus vulgaris Incidence (epidemiology) lcsh:R General Medicine medicine.disease biology.organism_classification Dermatology Surgery subcutaeneous mycoses Fonsecaea pedrosoi dematecious fungi Zygomycosis Post treatment business |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 9, Iss 12, Pp WC01-WC04 (2015) |
| Popis: | Introduction Verrucous plaques mimicking chromoblastomycosis are frequently seen in dermatology outpatient departments (OPD). However, no scientific evaluation has been carried out till date from eastern India. So this present endeavour is aimed at a thorough study of those cases to readdress the challenges in diagnosis and management in chromoblastomycosis from this part of the country. Aim The study is to observe the incidence of proved chromoblastomycosis cases from clinically mimicking conditions and to note therapeutic prospects by use of different antifungal agents. Materials and methods Twenty clinically suspected cases attending dermatology OPD were included in this study. Relevant histories were taken. Apart from routine hematological and biochemical investigations, scrapings from lesions were examined by direct microscopy with KOH wet mount, calcoflour white mount and fungal culture. Histopatholgical examination was also done. Any fungal growth was identified by growth characteristics and morphological features. Results Sclerotic bodies were detected in five samples. Of them three were found to be culture positive. Two growths were identified as Fonsecaea pedrosoi and one as Cladosporium carrionii. Rest 12 cases were diagnosed as either lupus vulgaris (3 cases; 15%), atypical mycobacterial infections (3 cases, 15%), Hypertrophic lichen planus (2, 10%), Hypertrophic DLE plaque (2; 10%), Wart (1, 5%) or fixed cutaneous sporothricosis (1, 5%), zygomycosis (1, 5%). Three cases (15%) were lost in follow up. Cases of chromoblastomycosis were managed with prolonged use of antifungal alone or in combination with saturated solution of potassium iodide and/or debridement. They were followed up for at least six months post treatment. Conclusion A database comprising diagnostic clues and effective therapeutic intervention have been proposed for these rare subcutaneous mycoses. |
| Databáze: | OpenAIRE |
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