Combined cis-Platinum plus Radiation Antitumor Activity in Locoregionally Advanced Squamous Cell Esophageal Cancer
| Autor: | Z. Tometic, A Roth, K Kolarić, J Luetić, D Zupanc, B Nagy |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Palliative care Esophageal Neoplasms Gastroenterology Internal medicine Biopsy Carcinoma medicine Mucositis Humans medicine.diagnostic_test business.industry Palliative Care General Medicine Middle Aged Esophageal cancer medicine.disease Combined Modality Therapy Bone marrow suppression Carcinoma Squamous Cell Vomiting Adenocarcinoma Female Cisplatin medicine.symptom business |
| Zdroj: | Oncology. 45:276-280 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000226622 |
| Popis: | The synergistic activity we have observed in vitro in V-79 hamster lung cells after treatment with cis-platinum combined with irradiation, stimulated a pilot study of 31 patients with inoperable locoregionally advanced squamous cell esophageal cancer. The 27 evaluable cases (22 men and 5 women--mean age 59 years) had undergone no prior radiation or cytostatic drug therapy. Histological evidence of the tumor (26 squamous cell, 1 adenocarcinoma) was obtained by endoscopy in all patients before treatment began. The patients were irradiated in two opposite thoracic fields with a total dosage of 3,000-4,000 cGy (200 cGy daily, 1,000 weekly) concurrently with 2 cycles of cis-platinum in the dosage of 30 mg/m2 iv. daily X 4 (120 mg/m2 per cycle). The results showed that cis-platinum combined with radiation showed an evident antitumor activity which included 4 complete clinical remissions and 11 partial remissions with a response rate of 56% (15/27). In two complete responders even a pathologic remission was evident (biopsy specimen) and they are now 16+ and 18+ months free of the disease. The median remission duration has been 8+ months (14+ months in complete responders) and the median survival period for the entire group is 10+ months (for responders 15+ months, p less than 0.05). Toxicity was moderate and reversible, and mainly accounted for radiation mucositis, retrosternal pain and vomiting. A mild bone marrow suppression was observed. In 2 cases esophagotracheal fistulae occurred. The results of this study show that the combination of cis-platinum and radiation might constitute successful palliative or neoadjuvant treatment for squamous cell esophageal cancer. |
| Databáze: | OpenAIRE |
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