Higher risk of kidney graft failure in the presence of anti-angiotensin II type-1 receptor antibodies
| Autor: | Robert C. Harland, K. Parker, Kimberly P. Briley, J. Hopfield, Scott A. Kendrick, Paul Bolin, W. Kendrick, Paul I. Terasaki, Paul G. Catrou, Carl E. Haisch, J. Cai, Lorita M. Rebellato, M. Taniguchi |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Graft failure Biopsy Enzyme-Linked Immunosorbent Assay Therapeutic targeting Gastroenterology Receptor Angiotensin Type 1 HLA Antigens Internal medicine Immunology and Allergy Medicine Humans Transplantation Homologous Pharmacology (medical) Receptor Kidney transplantation Autoantibodies Immunosuppression Therapy Transplantation Entire population Kidney biology business.industry Graft Survival Middle Aged medicine.disease Prognosis Angiotensin II Kidney Transplantation Surgery Survival Rate medicine.anatomical_structure Case-Control Studies biology.protein Female Kidney Diseases Antibody business Follow-Up Studies |
| Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 13(10) |
| ISSN: | 1600-6143 |
| Popis: | Reports have associated non-HLA antibodies, specifically those against angiotensin II type-1 receptor (AT1R), with antibody-mediated kidney graft rejection. However, association of anti-AT1R with graft failure had not been demonstrated. We tested anti-AT1R and donor-specific HLA antibodies (DSA) in pre- and posttransplant sera from 351 consecutive kidney recipients: 134 with biopsy-proven rejection and/or lesions (abnormal biopsy group [ABG]) and 217 control group (CG) patients. The ABG's rate of anti-AT1R was significantly higher than the CG's (18% vs. 6%, p |
| Databáze: | OpenAIRE |
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