Lumpectomy and Breast Radiotherapy in Breast Cancer Patients with a Family History of Breast Cancer, Ovarian Cancer, or Both
| Autor: | Diana Hey, Josie Ponce, Kathryn Howell, Howard Shapiro, Charles E. Leonard, Lynda Smith, Ben Vernon, Xiolan Liang, Scot Sedlacek |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Genes BRCA2 Genes BRCA1 Breast Neoplasms Breast radiotherapy Mastectomy Segmental Breast cancer Ovarian carcinoma Internal medicine Internal Medicine medicine Humans Genetic Predisposition to Disease Registries Family history Probability Ovarian Neoplasms Analysis of Variance Univariate analysis business.industry Lumpectomy Cancer medicine.disease Survival Rate Treatment Outcome Mutation Female Surgery Neoplasm Recurrence Local Ovarian cancer business Follow-Up Studies |
| Zdroj: | The Breast Journal. 8:154-161 |
| ISSN: | 1524-4741 1075-122X |
| DOI: | 10.1046/j.1524-4741.2002.08307.x |
| Popis: | This article presents an outcomes review of breast cancer patients identified from the cancer registries of four area hospitals. These patients had family histories of breast cancer, ovarian carcinoma, or both and were treated with conservative surgery and radiation to the involved breast. Patients were as follows: group 1, one first-degree relative ( n = 165, one synchronous bilateral breast cancer); group 2, > or =2 first-degree relatives ( n = 21); group 3, one second-degree relative ( n = 20); and group 4, > or =2 second-degree relatives ( n = 18). The total of patients and breast cancer events was 224 and 225, respectively. Group 5 was a subgroup of 53 patients with a substantial risk (>10%) of a BRCA1 or BRCA2 mutation. After a median follow-up of 3.9 years, 5 patients had local failure (2%), and 5 developed a contralateral breast cancer (2%). There were no significant differences in local failure rates between groups (p = 1.0): group 1, 5 of 166 (3%); group 2, 0 of 21 (0%); group 3, 0 of 20 (0%); and group 4, 0 of 18 (0%). Local failure for group 5 was 2% (1 of 53). Four of 143 patients (3%) with a minimum 3 years of follow-up (median, 5.6 years) had local failure, and 5 (4%) developed a contralateral breast cancer. A univariate analysis was statistically significant for differentiation only (well, 0 of 67; moderately, 1 of 57 [1.8%]; poor, 3 of 26 [11.5%], p = 0.008). Overall survival for groups 1-4 did not differ significantly. Although follow-up has been relatively short, we have not found that breast cancer patients with various degrees of family histories of breast/ovarian carcinoma have had a detrimental outcome when treated with conservative therapy. |
| Databáze: | OpenAIRE |
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