| Autor: |
O. Taby, D. Prasa, J. Stürzebecher |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Thrombosis research. 69(6) |
| ISSN: |
0049-3848 |
| Popis: |
In studies on the inhibition of activated protein C (APC) by benzamidine derivatives potent inhibitors of APC were found among anilides of 4-amidinophenyl-α-aminobutyric acid (K i = 0.58 μmol/1). Several bis-benzamidine derivatives containing a cycloalkanone linking bridge inhibit APC with K i values near the micromolar range. Potent and selective inhibitors of thrombin derived from 3- and 4-amidinophenylalanine do not inhibit APC. This is of great importance for further development of these inhibitors as potential anticoagulant drugs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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