Hyperprolactinemia contributes to reproductive deficit in male rats chronically administered PDE5 inhibitors (sildenafil and tadalafil) and opioid (tramadol)
| Autor: | E. E. Osim, Victor Udo Nna, U. P. Akpan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Sildenafil lcsh:Medicine Plant Science Phosphodiesterase-5 03 medical and health sciences Follicle-stimulating hormone chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine Testosterone Tramadol 030219 obstetrics & reproductive medicine General Veterinary business.industry lcsh:R Obstetrics and Gynecology Prolactin Tadalafil Hyperprolactinemia Endocrinology Reproductive Medicine Opioid chemistry Animal Science and Zoology business Luteinizing hormone 030217 neurology & neurosurgery Gonadotropins medicine.drug |
| Zdroj: | Asian Pacific Journal of Reproduction, Vol 5, Iss 5, Pp 381-386 (2016) |
| ISSN: | 2305-0500 |
| Popis: | Objectives: To examine the influence of prolonged use of PDE5 inhibitors and opioids on prolactin among other male reproductive hormones, on the background that hyperprolactinemia has recently been associated with male sterility. Materials and methods: Seventy male Wistar rats with weight 180–200 g were utilized in this study. They were assigned 1 of 5 groups (n = 14) as follows; control (0.2 mL normal saline p.o.), sildenafil (10 mg/kg p.o.), tadalafil (10 mg/kg p.o.), tramadol (20 mg/kg p.o.) and sildenafil + tramadol group (10 mg/kg and 20 mg/kg p.o., respectively). All the animals had ad libitum access to rat chow and water. Administration was done every 2 days, for 8 weeks, after which 7 rats were killed/group while the remaining 7 rats/group were left untreated for additional 8 weeks (recovery period). Serum total cholesterol, low density lipoprotein, testosterone, follicle stimulating hormone, luteinizing hormone and prolactin were assessed in all animals. Results: Serum LDL-c and testosterone concentrations increased significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|