Spectroscopic Characterization of 3-Aminoisoxazole, a Prebiotic Precursor of Ribonucleotides
| Autor: | Alessio Melli, Mattia Melosso, Kevin G. Lengsfeld, Luca Bizzocchi, Víctor M. Rivilla, Luca Dore, Vincenzo Barone, Jens-Uwe Grabow, Cristina Puzzarini |
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| Přispěvatelé: | Melli, Alessio, Melosso, Mattia, Lengsfeld, Kevin G, Bizzocchi, Luca, Rivilla, Víctor M, Dore, Luca, Barone, Vincenzo, Grabow, Jens-Uwe, Puzzarini, Cristina |
| Rok vydání: | 2022 |
| Předmět: |
rotational spectroscopy
large amplitude motion astrochemistry prebiotic molecules origin of life Earth Planet prebiotic molecule Spectrum Analysis Organic Chemistry Pharmaceutical Science Ribonucleotides Analytical Chemistry Chemistry (miscellaneous) Drug Discovery Molecular Medicine Physical and Theoretical Chemistry Microwaves Microwave Spectrum Analysi |
| Zdroj: | Molecules; Volume 27; Issue 10; Pages: 3278 |
| ISSN: | 1420-3049 |
| Popis: | The processes and reactions that led to the formation of the first biomolecules on Earth play a key role in the highly debated theme of the origin of life. Whether the first chemical building blocks were generated on Earth (endogenous synthesis) or brought from space (exogenous delivery) is still unanswered. The detection of complex organic molecules in the interstellar medium provides valuable support to the latter hypothesis. To gather more insight, here we provide the astronomers with accurate rotational frequencies to guide the interstellar search of 3-aminoisoxazole, which has been recently envisaged as a key reactive species in the scenario of the so-called RNA-world hypothesis. Relying on an accurate computational characterization, we were able to register and analyze the rotational spectrum of 3-aminoisoxazole in the 6–24 GHz and 80–320 GHz frequency ranges for the first time, exploiting a Fourier-transform microwave spectrometer and a frequency-modulated millimeter/sub-millimeter spectrometer, respectively. Due to the inversion motion of the −NH2 group, two states arise, and both of them were characterized, with more than 1300 lines being assigned. Although the fit statistics were affected by an evident Coriolis interaction, we were able to produce accurate line catalogs for astronomical observations of 3-aminoisoxazole. |
| Databáze: | OpenAIRE |
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