Mutual interdependence of splicing and transcription elongation
| Autor: | Grzegorz Brzyżek, Szymon Świeżewski |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Transcription
Genetic RNA Splicing Exonic splicing enhancer RNA polymerase II Biology chromatin and transcription Biochemistry transcription and RNA processing splicing Splicing factor Genetics Humans Point-of-View transcription elongation RNA polymerase II holoenzyme Eukaryotic transcription General transcription factor Intron chromatin marks PolII Chromatin Cell biology RNA splicing biology.protein Transcription factor II F RNA Polymerase II co-trancriptional splicing Biotechnology |
| Zdroj: | Transcription |
| ISSN: | 2154-1272 2154-1264 |
| DOI: | 10.1080/21541264.2015.1040146 |
| Popis: | Transcription and splicing are intrinsically linked, as splicing needs a pre-mRNA substrate to commence. The more nuanced view is that the rate of transcription contributes to splicing regulation. On the other hand there is accumulating evidence that splicing has an active role in controlling transcription elongation by DNA-dependent RNA polymerase II (RNAP II). We briefly review those mechanisms and propose a unifying model where splicing controls transcription elongation to provide an optimal timing for successive rounds of splicing. |
| Databáze: | OpenAIRE |
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