Quantum Dot Biosensors for Ultrasensitive Multiplexed Diagnostics
| Autor: | Loïc J. Charbonnière, Daniel Geißler, Raymond Ziessel, Nathaniel G. Butlin, Hans-Gerd Löhmannsröben, Niko Hildebrandt |
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| Rok vydání: | 2010 |
| Předmět: |
Detection limit
Diagnostic Tests Routine Chemistry Nanotechnology Biosensing Techniques 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Sensitivity and Specificity 01 natural sciences Multiplexing Catalysis 0104 chemical sciences 3. Good health Förster resonance energy transfer Semiconductor quantum dots Quantum dot Quantum Dots Fluorescence Resonance Energy Transfer 0210 nano-technology Biosensor Institut für Biochemie und Biologie |
| Zdroj: | Angewandte Chemie International Edition Angewandte Chemie International Edition; Vol 49 |
| ISSN: | 1433-7851 |
| Popis: | Time- and color-resolved detection of Foerster resonance energy transfer (FRET) from luminescent terbium complexes to different semiconductor quantum dots results in a fivefold multiplexed bioassay with sub-picomolar detection limits for all five bioanalytes (see picture). The detection of up to five biomarkers occurs with a sensitivity that is 40-240-fold higher than one of the best-established single-analyte reference assays. |
| Databáze: | OpenAIRE |
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