A Delicate Connection: c-di-AMP Affects Cell Integrity by Controlling Osmolyte Transport
| Autor: | Johannes Gibhardt, Jan Gundlach, Sven Halbedel, Jörg Stülke, Fabian M. Commichau |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Staphylococcus aureus 030106 microbiology Turgor pressure Bacillus subtilis Gram-Positive Bacteria Second Messenger Systems Microbiology Bacterial cell structure Cell wall 03 medical and health sciences Osmoregulation Bacterial Proteins Cell Wall Virology Cyclic AMP biology Cell Membrane Membrane Transport Proteins biology.organism_classification Listeria monocytogenes Cell biology Phenotype Infectious Diseases Biochemistry Osmolyte Second messenger system Cell envelope Bacteria |
| Zdroj: | Trends in Microbiology. 26:175-185 |
| ISSN: | 0966-842X |
| DOI: | 10.1016/j.tim.2017.09.003 |
| Popis: | Bacteria use second-messenger molecules to adapt to their environment. Several second messengers, among them cyclic di-AMP (c-di-AMP), have been discovered and intensively studied. Interestingly, c-di-AMP is essential for growth of Gram-positive bacteria such as Bacillus subtilis, Listeria monocytogenes, and Staphylococcus aureus. Many studies demonstrated that perturbation of c-di-AMP metabolism affects the integrity of the bacterial cell envelope. Therefore, it has been assumed that the nucleotide is essential for proper cell envelope synthesis. In this Opinion paper, we propose that the cell envelope phenotypes caused by perturbations of c-di-AMP metabolism can be interpreted differently: c-di-AMP might indirectly control cell envelope integrity by modulating the turgor, a physical variable that needs to be tightly adjusted. We also discuss open questions related to c-di-AMP metabolism that need to be urgently addressed by future studies. |
| Databáze: | OpenAIRE |
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