Angiogenesis in renal cell carcinoma: correlation of microvessel density and microvessel area with other prognostic factors
| Autor: | Manoj K. Singh, Siddhartha Datta Gupta, Shree Gopal Sharma, Nidhi Aggarwal, Ruchika Gupta, Amit K. Dinda |
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| Rok vydání: | 2006 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Pathology Proliferation index Angiogenesis Urology Cell Count Metastasis Correlation Renal cell carcinoma Internal medicine medicine Humans Microvessel Carcinoma Renal Cell Aged Neoplasm Staging Retrospective Studies Neovascularization Pathologic business.industry Middle Aged medicine.disease Prognosis Immunohistochemistry Kidney Neoplasms Ki-67 Antigen Microvessels cardiovascular system Disease Progression Female business |
| Zdroj: | International urology and nephrology. 43(1) |
| ISSN: | 1573-2584 |
| Popis: | This study was aimed at evaluating the association between tumor vascularity and other known prognostic factors in different histopathological subtypes of renal cell carcinoma (RCC). In 41 cases of RCC, immunohistochemistry was performed using anti-CD34 antibody and Ki-67 (MIB-1). Microvessel density was estimated in an area of 0.23 mm2 representative of the highest microvessel density (“hot spot”). The microvessel area (MVA) was expressed as percentage of total tumor area occupied by vessels. Endothelial proliferation index (EPI) was determined from sections stained by Ki-67. The relationship between MVD, MVA, EPI and prognostic parameters of RCC like stage, grade and tumor cells proliferation index (TPI) was evaluated. The tumor MVA increased significantly with the higher stage of the tumor (P |
| Databáze: | OpenAIRE |
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