sFlt ‐1/ PlGF ratio and timing of delivery in early‐onset fetal growth restriction with antegrade umbilical artery flow

Autor: P.I. Gómez-Arriaga, Ignacio Herraiz, M.S. Quezada, J. Rodriguez-Calvo, Alberto Galindo, Cecilia Villalain
Rok vydání: 2020
Předmět:
Adult
Placental growth factor
Middle Cerebral Artery
medicine.medical_specialty
Time Factors
Gestational Age
Umbilical Arteries
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Pregnancy
Interquartile range
medicine.artery
medicine
Humans
Radiology
Nuclear Medicine and imaging
Prospective Studies
030212 general & internal medicine
Placenta Growth Factor
Fetus
Fetal Growth Retardation
Vascular Endothelial Growth Factor Receptor-1
030219 obstetrics & reproductive medicine
Radiological and Ultrasound Technology
Obstetrics
business.industry
Obstetrics and Gynecology
Gestational age
Umbilical artery
General Medicine
Delivery
Obstetric
Fetal Weight
Reproductive Medicine
Pulsatile Flow
embryonic structures
Middle cerebral artery
Female
business
Live Birth
Biomarkers
Soluble fms-like tyrosine kinase-1
Cohort study
Zdroj: Ultrasound in Obstetrics & Gynecology. 56:549-556
ISSN: 1469-0705
0960-7692
Popis: To analyze the value of the soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PlGF) ratio in predicting the time to delivery in early-onset fetal growth restriction (FGR) with preserved antegrade umbilical artery (UA) flow at diagnosis.This was a prospective observational single-center cohort study of pregnancies with early-onset ( 32 + 0 weeks) FGR and antegrade UA flow, in which maternal serum sFlt-1/PlGF ratio was determined at diagnosis. FGR was defined as estimated fetal weight 3In total, 120 cases were included. There were 116 (96.7%) liveborn neonates and 108 (90.0%) perinatal survivors. Median (interquartile range (IQR)) gestational age at diagnosis of early-onset FGR was 27.1 (25.7-29.4) weeks. Median (IQR) sFlt-1/PlGF ratio at diagnosis was 196 (84-474). Ninety (75.0%) cases had a sFlt-1/PlGF ratio ≥ 85. Among pregnancies with a liveborn neonate, median (IQR) interval to delivery in the groups with sFlt-1/PlGF ratio 85 and ≥ 85 was 41 (22-54) days and 11 (4-20) days, respectively (P 0.01). The probability of having to deliver within 1 week after diagnosis was 0% and 35.6% in those with sFlt-1/PlGF ratio 85 and ≥ 85, respectively (P = 0.03), and the probability of delaying delivery for ≥ 4 weeks was 72.4% and 19.5%, respectively (P 0.01).sFlt-1/PlGF ratio 85 at diagnosis of early-onset FGR with antegrade UA flow identifies a group of pregnancies in which the need to deliver within 1 week is very low and the interval to delivery is expected to be prolonged for ≥ 4 weeks in 70% of cases. Copyright © 2019 ISUOG. Published by John WileySons Ltd.
Databáze: OpenAIRE
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