In vivo evaluation of insect wax for hair growth potential

Autor: Jinju Ma, Zhang Zhongquan, Wang Youqiong, Ma Liyi, Kai Li, Chen Xiaoming, Hong Zhang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Vascular Endothelial Growth Factor A
Hair Growth
Insecta
Physiology
lcsh:Medicine
Insect
Biochemistry
030207 dermatology & venereal diseases
chemistry.chemical_compound
Mice
0302 clinical medicine
Medicine and Health Sciences
lcsh:Science
media_common
Skin
Wax
Multidisciplinary
integumentary system
Chemistry
Eukaryota
Telogen Phase
Lipids
Vascular endothelial growth factor
Insects
Minoxidil
visual_art
Physical Sciences
visual_art.visual_art_medium
Organic Materials
Anatomy
Integumentary System
medicine.drug
Research Article
Arthropoda
media_common.quotation_subject
Materials Science
Andrology
Hair growth
03 medical and health sciences
In vivo
Hair Follicles
medicine
Animals
Policosanol
lcsh:R
Anagen Phase
Organisms
Biology and Life Sciences
medicine.disease
Invertebrates
030104 developmental biology
Hair loss
Waxes
lcsh:Q
Physiological Processes
Oils
Hair
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0192612 (2018)
ISSN: 1932-6203
Popis: Insect wax is secreted by Ericerus pela Chavanness. It has been traditionally used to treat hair loss in China, but few reports have been published on the hair growth-promoting effect of insect wax. In this work, we examined the hair growth-promoting effects of insect wax on model animals. Different concentrations of insect wax were topically applied to the denuded backs of mice, and 5% minoxidil was applied topically as a positive control. We found that insect wax significantly promoted hair growth in a dose-dependent manner, 45% and 30% insect wax both induced hair to regrow, while less visible hair growth was observed in blank controls on the 16th day. The experimental areas treated with 45% and 30% insect wax exhibited significant differences in hair scores compared to blank controls, and hair lengths in the 45% and 30% insect wax group was significantly longer than in blank controls on the 16th and 20th days. There were no new hair follicles forming in the treated areas, and the hair follicles were prematurely converted to the anagen phase from the telogen phase in experimental areas treated with 45% and 30% insect wax. Both 45% and 30% insect wax upregulated vascular endothelial growth factor expression. The results indicated that 45% and 30% insect wax showed hair growth-promoting potential approximately as potent as 5% minoxidil by inducing the premature conversion of telogen-to-anagen and by prolonging the mature anagen phase rather than increasing the number of hair follicles, which was likely related to the upregulation of VEGF expression. The dissociative policosanol in insect wax was considered the key ingredient most likely responsible for the hair growth promoting potential.
Databáze: OpenAIRE
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