Radiation-induced brain injury: retrospective analysis of twelve pathologically proven cases
| Autor: | Yeon-Sil Kim, Yong-Kil Hong, Young-Nam Kang, Sei-Chul Yoon, Youn-Soo Lee, Hong-Seok Jang, Dong-Chul Kim, Byung-Ock Choi, Sin-Soo Jeun, Mina Yu, Dong Soo Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Chemotherapy business.industry medicine.medical_treatment Brain tumor Subgroup analysis Radiation necrosis medicine.disease complex mixtures Radiosurgery Surgery Meningioma Radiation therapy Oncology Chemoradiation medicine Radiology Nuclear Medicine and imaging Original Article Radiology Oligodendroglioma Clinical Investigation Radiation injury business Brain metastasis |
| Zdroj: | Radiation Oncology Journal |
| ISSN: | 2234-3164 2234-1900 |
| Popis: | Purpose: This study was designed to determine the influencing factors and clinical course of pathologically proven cases of radiation-induced brain injury (RIBI). Materials and Methods: The pathologic records of twelve patients were reviewed; these patients underwent surgery following radiotherapy due to disease progression found by follow-up imaging. However, they were fi nally diagnosed with RIBI. All patients had been treated with 3-dimensional conventional fractionated radiotherapy and/or radiosurgery for primary or metastatic brain tumors with or without chemotherapy. The histological distribution was as follows: two falx meningioma, six glioblastoma multiform (GBM), two anaplastic oligodendroglioma, one low grade oligodendroglioma, and one small cell lung cancer with brain metastasis. Results: Radiation necrosis was noted in eight patients and the remaining four were diagnosed with radiation change. Gender (p = 0.061) and biologically equivalent dose (BED)3 (p = 0.084) were the only marginally infl uencing factors of radiation necrosis. Median time to RIBI was 7.3 months (range, 0.5 to 61 months). Three prolonged survivors with GBM were observed. In the subgroup analysis of high grade gliomas, RIBI that developed |
| Databáze: | OpenAIRE |
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