Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination

Autor:	Masanobu, Tanemoto, Ryosuke, Oda, Yuichiro, Toyama, Hirohiko, Shizukawa, Kazuki, Yokokawa, Taro, Saito, Syuuichirou, Suzuki, Akihiro, Matsumura, Shin, Hisahara
Rok vydání:	2022
Předmět:	Adult COVID-19 Vaccines SARS-CoV-2 Vaccination COVID-19 Myalgia General Medicine Muscular Diseases Internal Medicine Humans Female Signal Recognition Particle 2019-nCoV Vaccine mRNA-1273 Autoantibodies
Zdroj:	Internal Medicine. 61:3605-3609
ISSN:	1349-7235 0918-2918
DOI:	10.2169/internalmedicine.0404-22
Popis:	A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e51d78a7f6a708c867c0babcf2e3844 https://doi.org/10.2169/internalmedicine.0404-22 Zobrazit plný text záznamu