Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model
| Autor: | In-Ho Bae, Myung Ho Jeong, Sun-Jung Song, Doo Sun Sim, Yong Sook Kim, Young Joon Hong, Dong Lyun Cho, Hye-yun Jeong, Jong Min Kim, Kyung Seob Lim, Youngkeun Ahn, Keun-Ho Park, Dae Sung Park, Jung Ha Kim, Jun-Kyu Park, Eun Ju Yang, Hyung-Seok Kim |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Neointima medicine.medical_specialty Time Factors Polymers Swine Abciximab medicine.medical_treatment Fibrin Percutaneous coronary intervention Coronary Restenosis Immunoglobulin Fab Fragments Restenosis Internal medicine Animals Medicine Titanium Inflammation Neointimal hyperplasia Hyperplasia Thioctic Acid biology business.industry Antibodies Monoclonal Stent Drug-Eluting Stents medicine.disease Coronary arteries Disease Models Animal Treatment Outcome medicine.anatomical_structure biology.protein Cardiology Stents business Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Journal of Cardiology. 64(5):409-418 |
| ISSN: | 0914-5087 |
| DOI: | 10.1016/j.jjcc.2014.02.015 |
| Popis: | Background Polymer-free drug-eluting stents (DES) may overcome the shortcomings of polymer-based DES. The aim of this study was to examine the effect of the polymer-free TiO 2 film-coated stent with abciximab or alpha lipoic acid in a porcine coronary overstretch restenosis model. Methods Pigs were randomized into four groups in which the coronary arteries (24 pigs, 48 coronaries in each group) had TiO 2 film-coated stent with abciximab (TCA, n = 12), TiO 2 film-coated stent with alpha lipoic acid (TCALA, n = 12), biolimus A9-eluting stents with biodegradable polymer (BES, n = 12), and TiO 2 film-coated stent (TCstent, n = 12). Histopathologic analysis was performed at 28 days after stenting. Results There was no significant difference in the injury score and internal elastic lamina (IEL) among the four groups. There were significant differences in the lumen area, neointima area, percent area stenosis, fibrin score, and inflammation score among the four groups [2.7 ± 1.0 mm 2 , 2.6 ± 0.94 mm 2 , 48.9 ± 16.25%, 1.0 (range 0.0–3.0), 1.0 (range 0.0–2.0) in TCA stent group vs. 2.7 ± 1.24 mm 2 , 2.9 ± 0.83 mm 2 , 53.5 ± 17.19%, 1.0 (range 0.0–2.0), 1.0 (range 0.0–2.0) in TCALA stent group vs. 2.7 ± 1.30 mm 2 , 2.6 ± 1.06 mm 2 , 50.1 ± 23.20%, 2.0 (range 1.0–3.0), 2.0 (range 1.0–3.0) in BES group vs. 1.7 ± 0.63 mm 2 , 3.3 ± 0.58 mm 2 , 60.2 ± 10.12%, 0.5 (range 0.0–2.0), 1.0 (range 0.0–2.0) in TC stent group, respectively]. Conclusion TCA and TCALA are more effective to reduce neointimal hyperplasia compared to TC. Moreover, fibrin and inflammation scores are significantly lower in TCA and TCALA than BES in porcine coronary restenosis model. |
| Databáze: | OpenAIRE |
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