Protein S, an Antithrombotic Factor, Is Synthesized and Released by Neural Tumor Cells
| Autor: | Hooper Wc, M Ribeiro, Bruce L. Evatt, Greengard Js, John H. Griffin, José A. Fernández, Donald J. Phillips |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.diagnostic_test
Brain Neoplasms Blotting Western Enzyme-Linked Immunosorbent Assay Biology Biochemistry Molecular biology Protein S Endothelial stem cell Blot Cellular and Molecular Neuroscience Fibrinolytic Agents Western blot Cell culture Tumor Cells Cultured medicine biology.protein Vitronectin Fibrinolytic agent Protein C medicine.drug |
| Zdroj: | Journal of Neurochemistry. 61:344-347 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1111/j.1471-4159.1993.tb03574.x |
| Popis: | Protein S, an anticoagulant factor in the protein C antithrombotic pathway, was found to be synthesized and released by six tumor cell lines of neural origin by western blotting and ELISA. The rate of synthesis ranged from three- to 11-fold higher than that of a microvascular endothelial cell line and 36-144% that of a hepatoma cell line. The secreted protein S displayed specific anticoagulant activity similar to that of purified plasma protein S, implying that it was fully gamma-carboxylated. Ten primary brain tumor tissues also expressed protein S antigen, as shown by western blot analysis. Expression of anticoagulantly active protein S by neural cells raises important questions concerning possible physiologic roles for this multidomain protein beyond its function in control of thrombosis. |
| Databáze: | OpenAIRE |
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