Malignant Chondroid Syringoma: A Report of Two Cases with a Sarcomatous Mesenchymal Component
| Autor: | Wayne Grayson, Carolina Nel, Dawn van der Byl |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Mesenchymal stem cell carcinosarcoma Case Report Context (language use) lcsh:RL1-803 Liposarcoma medicine.disease behavioral disciplines and activities humanities medicine.anatomical_structure Chondroid Syringoma Scalp Adnexal Neoplasms Malignant Mixed Tumour Carcinosarcoma lcsh:Dermatology medicine Neoplasm Osteosarcoma Malignant chondroid syringoma business Skin |
| Zdroj: | Dermatopathology Volume 6 Issue 2 Pages 77-84 Dermatopathology, Vol 6, Iss 2, Pp 77-84 (2019) |
| ISSN: | 2296-3529 |
| DOI: | 10.1159/000495610 |
| Popis: | Malignant chondroid syringoma (MCS malignant mixed tumour) is a rare neoplasm typically arising on the extremities and trunk. We are report 2 unique cases of MCS, one occurring on the scalp of a 78-year-old man and the other on the trunk of a 72-year-old woman. Both tumours harboured malignant epithelial and malignant mesenchymal components. The latter was represented by liposarcoma in the first case. The malignant components of the second tumour comprised spindle cell squamous cell carcinoma (SCC) and osteosarcoma. Origin from a pre-existing benign chondroid syringoma was clearly evident in both neoplasms. The presence of heterologous malignant mesenchymal components, however, is hitherto unreported in the context of MCS, while a spindle cell SCC component is exceptionally rare. The 2 cases presented herein highlight an expanded morphological spectrum of MCS, with resultant blurring of the boundaries between MCS and cutaneous carcinosarcoma. |
| Databáze: | OpenAIRE |
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