A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types
| Autor: | Kamesh R. Babu, Siqin Zhou, Zhi Hao Kwok, Yvonne Tay, Jia Li, Henry Yang, Bin Zhang, Chun You Lim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Epigenomics
DNA Copy Number Variations RNA-binding protein Computational biology Biology Epigenesis Genetic Expression landscape 03 medical and health sciences 0302 clinical medicine Immune system Downregulation and upregulation Neoplasms medicine Tumor Microenvironment cancer Humans Gene Regulatory Networks Molecular Biology 030304 developmental biology 0303 health sciences Gene Expression Profiling RNA Cancer Computational Biology RNA-Binding Proteins Translation (biology) Cell Biology medicine.disease RNA binding protein Gene Expression Regulation Neoplastic 030220 oncology & carcinogenesis RNA splicing Transcriptome Human cancer Research Paper |
| Zdroj: | RNA Biology |
| ISSN: | 1555-8584 1547-6286 |
| Popis: | RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and translation. Despite their dysregulation in various diseases including cancer, the landscape of RBP expression in human cancer has not been well elucidated. Here, we built a comprehensive expression landscape of 1504 RBPs across 16 human cancer types, which revealed that RBPs are predominantly upregulated in tumours and this phenomenon is affected by the tumour immune subtypes and microenvironment. Across different cancer types, 109 RBPs are consistently upregulated while 41 RBPs are consistently downregulated. These up-regulated and down-regulated RBPs show distinct molecular characteristics and prognostic effects, whereas their dysregulation is mediated by distinct cis/trans-regulatory mechanisms. Finally, we validated one candidate PABPC1L that might promote colon tumorigenesis by regulating mRNA splicing. In summary, we built a comprehensive expression landscape of RBPs across different cancer types and identified consistently dysregulated RBPs which could be novel targets for developing broad-spectrum anticancer agents. |
| Databáze: | OpenAIRE |
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