Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives
| Autor: | Şeref Demirayak, Yağmur Tunalı, Murat Duran, Leyla Yurttaş, Huelya Karaca Gencer |
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| Přispěvatelé: | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Yurttaş, Leyla, Demirayak, Şeref, Karaca Gencer, Hülya, Tunalı, Yağmur |
| Rok vydání: | 2013 |
| Předmět: |
Antifungal
Antifungal Agents medicine.drug_class Cell Survival Clinical Biochemistry Pharmaceutical Science Thio Antineoplastic Agents Microbial Sensitivity Tests Gram-Positive Bacteria Biochemistry chemistry.chemical_compound Structure-Activity Relationship Cell Line Tumor Drug Discovery Gram-Negative Bacteria medicine Imidazole Organic chemistry Animals Humans Brine-Shrimp Test Molecular Biology Biological evaluation Chemistry Aryl Organic Chemistry Imidazoles Antimicrobial Combinatorial chemistry Anti-Bacterial Agents Anticancer Molecular Medicine Artemia Drug Screening Assays Antitumor |
| Zdroj: | Bioorganicmedicinal chemistry letters. 23(24) |
| ISSN: | 1464-3405 0003-2778 |
| Popis: | WOS: 000327787700045 PubMed ID: 24176398 In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds |
| Databáze: | OpenAIRE |
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