Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome
| Autor: | Charles B. Berde, Simona Sava, Athena M. Drosos, Navil F. Sethna, Laura E. Simons, David Borsook, Alyssa Lebel, Lino Becerra |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Rest Cognitive Neuroscience Psychological intervention Pain Disease Neuropsychological Tests lcsh:Computer applications to medicine. Medical informatics Brain mapping lcsh:RC346-429 Article Salience Physical medicine and rehabilitation medicine Humans Radiology Nuclear Medicine and imaging Resting state Children lcsh:Neurology. Diseases of the nervous system Default mode network Brain Mapping medicine.diagnostic_test Resting state fMRI fMRI Brain Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Reflex Sympathetic Dystrophy Complex regional pain syndrome Neurology Neuropathic pain lcsh:R858-859.7 Female Neurology (clinical) Nerve Net Psychology Neuroscience |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 6, Iss C, Pp 347-369 (2014) |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2014.07.012 |
| Popis: | Pediatric complex regional pain syndrome (P-CRPS) offers a unique model of chronic neuropathic pain as it either resolves spontaneously or through therapeutic interventions in most patients. Here we evaluated brain changes in well-characterized children and adolescents with P-CRPS by measuring resting state networks before and following a brief (median = 3 weeks) but intensive physical and psychological treatment program, and compared them to matched healthy controls. Differences in intrinsic brain networks were observed in P-CRPS compared to controls before treatment (disease state) with the most prominent differences in the fronto-parietal, salience, default mode, central executive, and sensorimotor networks. Following treatment, behavioral measures demonstrated a reduction of symptoms and improvement of physical state (pain levels and motor functioning). Correlation of network connectivities with spontaneous pain measures pre- and post-treatment indicated concomitant reductions in connectivity in salience, central executive, default mode and sensorimotor networks (treatment effects). These results suggest a rapid alteration in global brain networks with treatment and provide a venue to assess brain changes in CRPS pre- and post-treatment, and to evaluate therapeutic effects. Highlights • Pediatric complex regional pain syndrome (CRPS) alters brain networks. • Alterations are not equivalent to those observed in adults with CRPS. • Identifying alterations might be relevant to determine treatment modalities. • Intensive physical- and psycho-therapy reverses some but not all the changes. |
| Databáze: | OpenAIRE |
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